In summary:

– Kicking has been fixed and is much easier to control
– IR has been toned down a bit so it could be only used where needed
– Play calling and character switching is done with buttons
– Wii motion-controls are easier to use
– Each player will now use a profile at all times with Mii’s
– On-screen move suggestions are in the game
– New ability to “bluff” your coach’s cam when on the field
– Telestrator is like an instant replay with the ability to draw on the screen
– For Online, Madden will be using an EA player tag
– EA messenger will be part of Madden online
– Stat-streaming will be including in Madden

Link