Nintendo Wii

North America:
1. Resident Evil 4: Wii Edition (Capcom)
2. Wii Fit (Nintendo)
3. Mario Kart Wii (Nintendo)
4. Wii Play (Nintendo)
5. My Fitness Coach (Ubisoft)

Japan:
1. Wii Fit (Nintendo)
2. One Piece Unlimited Cruise: Episode 2 – Awake Valiant (Bandai)
3. New Wii Play Control! Pikmin (Nintendo)
4. Taiko: Drum Master Wii (Namco)
5. Wii Sports (Wii)

Europe:
1. Wii Fit (Nintendo)
2. My Fitness Coach (Ubisoft)
3. Mario Kart Wii (Nintendo)
4. The House of the Dead: Overkill (Sega)
5. Wii Play (Nintendo).

Nintendo DS

North America:
1. New Super Mario Bros. (Nintendo)
2. Mario Kart DS (Nintendo)
3. Mario Party DS (Nintendo)
4. Brain Age: Train Your Brain in Minutes a Day! (Nintendo)
5. Disney’s Club Penguin: Elite Penguin Force (Disney)

Japan:
1. Learn Bookkeeping The DS Way: LEC Nissho – Level 3 (Square Enix)
2. 7th Dragon (Sega)
3. Mario & Luigi RPG 3 (Nintendo)
4. Prince of Tennis Doubles no Oji-Sama: Girls, Be Gracious! (Konami)
5. Tokimeki Memorial Girl’s Side 1st Love Plus – Luxury CD Edition (Konami)

Europe:
1. Professor Layton and the Curious Village (Nintendo)
2. 100 Classic Book Collection (Nintendo)
3. Mystery Case Files: Millionheir (Nintendo)
4. Puzzler Collection (Ubisoft)
5. Dr. Kawashima’s Brain Training: How Old Is Your Brain? (Nintendo)

The Big Five is the top five selling games world wide according to Amazon.

Link