Eyeshield 21 for Wii is based off the popular anime/manga series written by Riichiro Inagaki and illustrated by Yusuke Murata…

…..As for the actual football mechanic, Eyeshield 21 takes a ton of inspiration from the previously-successful DS version. The game takes an extremely simplistic approach to American football, with the basic strategy being whether to pass, run to a side, run up the gut, or kick a field goal. On defense, simply select one of the four choices in an attempt to guess the play and gain an introductory edge on the offense.

eyeshild1.jpgeyeshild4.jpgeyshild1.jpgeyshild2.jpgeyshild3.jpg

Read a ton more info about Eye Shild at the source, talks about gamplay, also has a few more pics.

Source: IGN