Crytek, the maker of Crysis, says they are working on the Wii.  Even if it may be 2 or 3 years down the road.

“We have Wii development but it’s very small, it’s more like testing ideas. We don’t have a project at this stage. Nintendo Wii is certainly on the radar, we will do something for Nintendo Wii – the question is when. I think some time maybe in three or four years, but nobody knows when.”