George Harrison has confirmed in a Camp Hyrule Q&A session that the Wii version of Twilight Princess will not be compatible with the Gamecube controller. Here it is in his words:

“The GCN controller will be able to play the GCN version on the Wii console, but will not be able to play the Wii version.”

Seems logical but it’s been one of those slow days so there it is.

Source: Cubed3