I’ll spare you a lengthy “how to play Dr. Mario” portion because you probably know the basics. Match the colored pills on the viruses to wipe clear them from the container is how Dr. Mario worked on the NES. Dr. Mario on the Wii works the same way.

 However, when you start Dr. Mario & Saikin Bokumetsu you are given a choice between playing Dr. Mario or a new mode optimized for Wii remote control called Saikin Bokumetsu (Bacteria Exterminator). In this mode you point at the colored pills, press the A button and drag them into place. The “B” button is used to rotate them 90 degrees. Compared to regular Dr. Mario the pills crawl to the bottom of the screen, which on the surface sounds like you have plenty of time to react. In some sense this is true before the pieces fall you have more a few seconds to cogitate, but the screen is much smaller. There are only 36 blocks (6 x 6 board size) for viruses and pills in Saikin Bokumetsu compared to a wider and larger container in classic Dr. Mario. The screen starts filling up with pills as multiple doses of medicine drop from the top. Up to three pieces can fall at the same time.

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